This study was aimed at the question whether a ketogenic diet (KD) could have a role in preventing migraines.
Sixteen interictal migraine without aura patients underwent VEPs and median nerve recordings, before and during ketogenesis, confirmed by urinary sticks.
After 1-month of KD, a significant reduction of mean migraine frequency (from a mean of 4.1 to 1.4 attacks/month, p < 0.001) and duration (from 51.9 to 16.3 hours/month, p < 0.001) was observed.
The researchers found evidence for KD-induced changes at cortical level in parallel to an improvement of migraine.
“Since KD was able to restore normal EPs habituation curves during stimulus repetition without changing significantly early amplitude responses, the authors hypothesize that KD acts on habituation via an enhancement of late GABA inhibition.”
Bracaglia et al. Cortical functional correlates of responsiveness to short-lasting preventive intervention with ketogenic diet (KD) in migraine. The Journal of Headache and Pain 2015, 16(Suppl 1):A58